|
Alphabetical list of genes |
Genes E - F - G - H - I - J - K --[Genes A-D -- Genes L-R -- Genes S-Z ]
-
E
- E2F transcription factor
-
positively regulates genes involved in the S (DNA synthesis) phase of the cell cycle
- E2F transcription factor 2
-
negatively regulates genes involved in the S (DNA synthesis) phase of the cell cycle
- eagle
-
nuclear receptor - zinc finger - involved in the determination the cell fate of serotonergic neurons
- easter
-
required for establishment of embryonic polarity - serine protease, trypsin family - generates processed Späzle, which in turn acts as the Toll ligand
- ebi
-
Trp-Asp (WD) repeats protein - regulates Egfr pathway & protein degradation
- E-cadherin (preferred name: shotgun)
-
E-cadherin homolog - regulates cell aggregation preventing mixing of cells at tissue boundaries
- Ecdysis triggering hormone
- Regulates the process of preecdysis and ecdysis behaviors in the process shedding of the old cuticle
- Ecdysone-induced protein 75B
-
nuclear receptor - ensures proper temporal progression of larval development
- Ecdysone receptor
-
transcription factor - nuclear receptor - zinc finger - regulates molting cycles and oogenesis
- Ecdysone-induced protein 63E
-
cyclin dependent kinase that plays a role in cell differentiation rather than in cell division
- Ecdysone-induced protein 74EF
-
ETS domain transcription factor that encodes two isoforms that control the timing of gene induction during molting
- ecdysoneless
-
conserved protein of unknown function - mutants disrupt production of the steroid hormone ecdysone causing developmental and reproductive defects
- Eclosion hormone
-
neuropeptide - acts directly on the CNS to release the stereotyped motor programs that trigger the shedding of the old cuticle at the end of each molt
- echinoid & friend of echinoid
-
cell-adhesion molecules (CAMs) - Ig and fibronectin domains proteins - The genes are adjacent to one another and co-ordinately regulated - Echinoid acts to antagonize Egf receptor signaling - Friend of echinoid exhibits interaction with the Notch pathway
- eiger
-
TNF superfamily; type II membrane protein - ligand that induces cell death by activating the JNK pathway
- 18 wheeler
-
transmembrane - leucine-rich repeat motif (LRR) - a critical component of the humoral immune response
- Eip93F
-
Pipsqueak family transcription factor - programs a cell death response during larval development
- elbow B
-
zinc finger transcription factor - specifies distinct tracheal cell fates
- embryonic lethal abnormal vision (common alternative name: elav)
-
RNA binding protein - a pan-neural gene required for correct differentiation and maintenance of the nervous system
-
empty spiracles FlyExpress: ems head gap and neuroblast expression
-
transcription factor - homeodomain - required for head development and brain morphogenesis
- enabled
-
VASP homolog and SH3 domain protein - cytoskeletal adaptor protein implicated in axonal outgrowth and fasciculation
- encore
-
During oogenesis Encore physically interacts with the proteasome, protein degradation factor Cul1 and Cyclin E -
- In encore mutant germaria Cyclin E degradation is compromised, thus impairing exit from cystoblast cell divison
- In encore mutant germaria Cyclin E degradation is compromised, thus impairing exit from cystoblast cell divison
-
engrailed en segmental expression
-
transcription factor - homeodomain - engrailed class - segment polarity gene - involved in compartment identity and boundary formation
- Enhancer of bithorax
- major subunit of nucleosome remodeling factor (nurf) - multiple domain protein with HMGI/Y and bromodomain motifs
- Enhancer of Polycomb
-
novel Polycomb group protein and a suppressor of position effect variegation
- Enhancer of split
-
transcription factor - bHLH - Hairy/E(spl) class - neurogenic gene - target of Notch pathway
- E(spl) region transcript m7
- neurogenic bHLH transcription factor - Hairy/E(spl) class - an inhibitor of neural fate - Hairy/E(spl) class
- Enhancer of zeste
-
transcription factor - polycomb group with trithorax homology - chromatin associated
- Eph receptor tyrosine kinase
-
receptor tyrosine kinase involved in axon pathfinding
- Ephrin
- functions as a ligand for Eph receptor - expressed on the surface of neuron cell bodies - acts to confine Eph receptor bearing axons to longitudinal tracts by repulsion
- Epidermal growth factor receptor (common alternative name: Torpedo)
- transmembrane receptor- tk - EGF-R homology - during oogenesis helps set up egg polarity, determines the identity of cells in the ectoderm; during larval stages participates in the development of the eye and wing.
- erect wing
-
novel transcription factor - exhibits a neural defect due to expression in neurons and a muscle defect due to expression in myoblasts
- escargot
-
transcription factor - zinc finger - regulates the cell cycle in histoblasts
- E(spl) region transcript m4
-
Bearded family - required to positively transduce the Notch signal during neurogenesis, and presumably during bristle development as well
-
even-skipped
FlyExpress: eve segmental expression
- transcription factor - homeodomain - pair rule gene establishing epidermal cell fate
- expanded
-
Band 4.1 protein with three potential SH3-binding sites - localization to adherens junctions allows Expanded to exert effects on multiple processes
- involved in disc development, including effects on cell proliferation, cell fate determination, and tissue polarity
- involved in disc development, including effects on cell proliferation, cell fate determination, and tissue polarity
-
extra-extra
FlyExpress: exex anterior and posterior midgut and CNS expression
-
a homeodomain transcription factor - regulates motorneuron cell fate by restricting expression of Even-skipped and Lim2
- extra macrochaetae
-
transcription factor - HLH non basic - antagonist of proneural genes
- extra sexcombs
-
Polycomb group - WD40 domain - in combination with Enhancer of zeste and histone deacetylases, promotes gene silencing
- extradenticle
-
transcription factor - homeodomain - cooperatively interacts with homeotic proteins to increase the specificity of homeotic protein binding to DNA
- exuperantia
-
a core component of a large protein complex involved in localizing mRNAs both within nurse cells and the developing oocyte
- eyegone
-
transcription factor - homeodomain & pax domain - plays a role in the process of joining morphogenesis that is crucial to the formation of salivary gland ducts
- eyeless
-
transcription factor - homeodomain & pax domain - plays a crucial role in eye and brain development
- eyelid (preferred name: osa)
-
transcription factor - Bright family - associates with the Brahma chromatin remodeling complex - antagonizes Wingless signaling
- during Drosophila development and affects patterning of the eye imaginal disc
- during Drosophila development and affects patterning of the eye imaginal disc
-
eyes absent (preferred name: clift)
FlyExpress: eya head and mesodermal expression
-
transcriptional co-activator and protein tyrosine phosphatase - cell survival factor - functions in eye development -
- also plays a role in the embryonic determination of somatic gonadal precursor (SGP) cell fate
- also plays a role in the embryonic determination of somatic gonadal precursor (SGP) cell fate
- eyes closed
-
a fly homolog of p47, a protein co-factor of the p97 ATPase involved in membrane fusion - mutation results in a lethal failure of nuclear envelope assembly in early zygotic divisions and results in defective photoreceptor morphogenesis
- F
- F
- faint sausage
-
Ig superfamily - involved in neural cell migration and axon pathfinding
- Fasciclin I
-
lipid linked novel protein - homophilic cell adhesion molecule that acts in axon guidance
- Fasciclin II
-
transmembrane - NCAM homolog - Ig superfamily - controls number and stability of neuromuscular synapses
- Fasciclin III
-
transmembrane - cam - novel - aids in cell adhesion, axon pathfinding and fasciculation ensuring proper muscle innervation
- fat
-
cadherin domain transmembrane receptor that negatively controls cell proliferation - also functions in planar polarity
- fat facets
-
conserved Cys and His domains - ubiquitin-specific protease - plays multiple roles in eye and oocyte development
- fear of intimacy
-
transmembrane domain protein - FICL family - zinc transporter - required in the mesoderm for gonad morphogenesis - required for tracheal branch fusion
- female sterile (3) homeless (preferred name: spindle E)
-
DE-H family of RNA-dependent ATPases - possible roles during oocyte development in RNA processing, transport, or stabilization
- fgf-receptor homolog 1 (preferred name: heartless - common alternative name: DFR1)
- receptor tyrosine kinase - involved in the development of mesodermal and neuronal cells
- fizzy related (preferred name: retina aberrant in pattern)
- Trp-Asp repeat (WD-repeat) protein - negatively regulates the levels of cyclins A, B and B3 thus promoting mitosis
- flamingo (preferred name: starry night)
-
Cadherin-related 7TM protein involved in tissue polarity
- Fmr1
- KH domain RNA-binding protein - homolog of mammalian Fragile X mental retardation gene - represses Futsch translation - mutants have synaptic structural defects
- FMRFamide-related
-
neuropeptide of unknown function in Drosophila expressed in sets of brain and ventral cord neurons
- Focal adhesion kinase-like
-
involved in integrin signaling - targets multiple cytoskeletal and signal transduction proteins
- folded gastrulation
-
secreted - novel protein - regulates gastrulation - necessary for coordination of cell shape changes throughout the invaginating primordia
- foraging
- cGMP-dependent protein kinase - controls feeding behavior and locomotory behavior
-
fork head
FlyExpress: fkh expression in midgut primordia and salivary glands
-
transcription factor - forkhead domain - plays two roles for fkh in the formation of the embryonic salivary glands:
- an early role in promoting survival of the secretory cells, and a later role in secretory cell invagination
- an early role in promoting survival of the secretory cells, and a later role in secretory cell invagination
- Fos-related antigen (preferred name: kayak)
-
transcription factor - basic leucine zipper - regulates dorsal closure - also required downstream from Decapentaplegic signaling for the regulation of labial in the midgut
- four-jointed
-
type 2 transmembrane protein - conveys positional information in the leg and eye, perhaps acting downstream of Notch
- 14-3-3zeta (common alternative name name: leonardo)
-
a 14-3-3zeta isoform - a phosphoserine/threonine interacting protein - positively regulates
- Ras-mediated signaling in the development of the compound eye - also involved in facilitating olfactory learning
- Ras-mediated signaling in the development of the compound eye - also involved in facilitating olfactory learning
- foxo
- forkhead domain transcription factor - a target of the insulin receptor signaling pathway - modulates growth and proliferation
- frayed
-
serine/threonine kinase - PAK family - required for normal axonal ensheathment
- frazzled
-
Ig superfamily - functions as a Netrin receptor in axon pathfinding
- fringe
-
secreted glycosyltransferase involved boundary formation - Notch antagonist that functions by targeting extracellular domain of Notch
- frizzled
-
transmembrane - 7 pass - frizzled family - receptor for Wingless - tissue polarity gene
- frizzled2
-
transmembrane - 7 pass - frizzled family - receptor for Wingless - tissue polarity gene
- frizzled3
-
transmembrane - 7 pass - frizzled family - antagonizes wingless signal
- fruitless
-
zinc finger - sex determination - regulates mating behavior
- ftz transcription factor 1
-
transcription factor - nuclear receptor - zinc finger - bridges early and late gene expression during the process of metamorphosis
- FTZ-F2 (preferred name: tramtrack)
- transcription factor - zinc finger - represses neural cell fate in the peripheral nervous system
- furrowed
-
selectin (carbohydrate binding protein) - mutants have defects in eye patterning and in cell determination of the ommatidia and bristles
- fused
-
serine/threonine kinase - segment polarity gene - cytoplasmic component of Hedgehog signaling pathway
-
fushi tarazu
FlyExpress: ftz pair-rule expression
-
transcription factor - homeodomain - Antp class - pair rule gene
- futsch
-
microtubule-associated protein regulating axon guidance
- G
- G
- GAGA (preferred name: Trithorax like)
- transcription factor - zinc finger - btb domain - a transcriptional activator that functions by influencing chromatin structure
- gammy legs (preferred name: pygopus)
-
nuclear PHD-finger protein - a core component of the Wingless signaling pathway that acts downstream of or at the level of Pangolin
- gastrulation-defective
- a maternally supplied protease involved in establishment of dorsal/ventral polarity - targets Snake
- gata-2 (preferred name: pannier)
- transcription factor - zinc finger - GATA family - a local repressor of achaete and scute that is required for the normal pattern of sensory bristles
- GATAe FlyExpress: GATAe endodermal expression
- GATA family zinc finger transcription factor - Required downstream of serpent for the expression of specific genes in the differentiated midgut
- Gcn5 (preferred name: Pcaf)
- a major histone H3 acetylase in Drosophila that plays a key role in the control of specific morphogenetic cascades during developmental transitions
- geminin
- limits DNA replication by preventing Mcm loading onto chromatin
- Genghis Kahn
-
similar to myotonic dystrophy protein kinase - regulates cytoskeletal dynamics
- germ cell-less
- chromatin component - BTB/POZ domain protein- responsible for establishment transcriptional quiescence in germ cells
- giant
-
transcription factor - basic leucine zipper - gap gene
- gigas
-
Rap1 GAP domain protein - tuberous sclerosis-2 homolog - regulates growth rate - a modifies of the insulin pathway
- glass
-
transcription factor - zinc finger - required for normal development of photoreceptor cells in a larval photoreceptor known as Bolwig's
organ, in the adult compound eye and in adult simple eyes, known as ocelli
- glass bottom boat (common alternative name: Transforming growth factor beta at 60A)
- TGF-beta superfamily - BMP 7 homolog - potentiates dpp signaling
-
glial cells missing
FlyExpress: gcm glial expression
-
transcription factor - novel - required for glial cell fate
- Gliolectin
-
lectin (carbohydrate binding protein) - regulates cell adhesion in midline glia
- Gliotactin
-
transmembrane - novel serine esterase homolog - functions in glia to ensure a secure blood-brain barrier.
- gluon
-
condensin subunit SMC4 - involved in mitotic chromatin condensation
- Glutactin
-
basement membrane protein - secreted - carboxesterase domain - expressed in glia - mutants have defective blood-brain barrier
- Glutamate receptor IIA and Glutamate receptor IIB
-
transmembrane Ca2+ channel protein - expressed on muscular synaptic boutons targeted by motor neurons
- gooseberry-neuro (common alternative name: gsb-p)
- transcription factor - homeodomain - paired domain - regulates neuroblast cell fate - functions redundently with gooseberry
-
gooseberry (common alternative name: gsb-d)
FlyExpress: gsb segmental expression
- transcription factor - homeodomain - paired domain - regulates neuroblast cell fate
-
Goosecoid
FlyExpress: gsc head and brain expression
-
transcription factor - homeodomain - paired-like - regulates cell fate in the brain and stomatogastric nervous system
- G protein-coupled receptor kinase 2
-
Serine/threonine protein kinase - involved n a receptor-mediated signaling pathway that utilizes cAMP as a second messenger - involved in oogenesis and implicated in learning
- G protein oalpha 47A (common alternative name: brokenheart)
-
G protein alpha subunit - regulates mesenchymal-epithelial transition that takes place in cardial cells and precursor cells of the visceral musculature
- G protein salpha 60A
-
s-alpha subunit of heterotrimeric G protein - regulates cyclic AMP second messenger system - functions in learning
- grapes
-
kinase - Chk1 homolog - cell cycle checkpoint protein
- grain (common alternative name: dGATAc)
-
zinc finger - GATA family - required during development for shaping the adult legs and the larval posterior spiracles
- grainy head
-
transcription factor - basic HLH - cooperates with Suppressor of Hairless to activate Notch target genes
- grim
- pro-apoptotic protein whose N-terminus functions by disrupting IAP binding to caspases -
an additional mitochondrial-dependent apoptotic function carried out by a centrally located GH3 domain
- Grip
-
Scaffolding and signaling protein - participates in the reception of an attractive signal that emanates from muscle epidermal attachment sites to direct the motility of developing muscles
- groovin (preferred name: short stop)
-
cytoskeletal cross-linker protein - expressed in the
tendons and is essential for muscle-dependent tendon cell differentiation -
- required for sensory and motor axons to reach their targets in the Drosophila embryo
- required for sensory and motor axons to reach their targets in the Drosophila embryo
- groucho
-
transcription factor - WD40 domain - E(spl) complex - partners transcriptional repressors by functioning as a co-repressor
- Grunge
-
transcriptional cofactor for Even-skipped - positive regulator of teashirt - homolog of mammalian Atrophin
- GTPase-activating protein 1
-
Ras GTPase-activating protein with PH domain and C2-domain - functions in cone cell precursors to down-regulate Ras1
- guftagu (common alternative name: Cul-3)
- Cullen-3 homolog acting in protein degradation - loss of function has pleiotropic effects during development, including defects in external sensory organ development, pattern formation and cell growth and survival - targets Cubitus interruptus
- GUK-holder
-
Scaffolding protein involved in synaptic budding - interacts with the GUK domain of Discs large - required for the proper synaptic localization of Scribbled
- gurken
-
TGFß homolog - EGF-R ligand - required for dorsoventral patterning in the egg and embryo
- Gustatory receptor 68a
- an essential component of pheromone-driven courtship behavior
- gutfeeling (preferred name: Ornithine decarboxylase antizyme)
- modifies the activity of Ornithine decarboxylase - regulates the nuclear entry and overall levels of Sex-lethal in early germ cells
- H
- H
- H15 and midline
- T-box transcription factors that participate in cardiac fate specificity
- Hairless
-
novel basic protein - a major antagonist of the Notch signaling-pathway - associates with Suppressor of Hairless, thereby inhibiting
trans-activation of Notch target genes
- hairy
-
transcription factor - bHLH - Hairy/E(spl) class - during embryogenesis it participates as a primary pair-rule gene in the establishment of segments -
- in the larval stage it functions negatively in determining the pattern of sensory bristles on the adult fly.
- in the larval stage it functions negatively in determining the pattern of sensory bristles on the adult fly.
- half pint (preferred name: poly-U-binding splicing factor)
- RNA recognition motif protein - functions in both constitutive and alternative splicing - required during oogenesis
- hamlet
- zinc finger - regulates cell identity in the peripheral nervous system - a binary genetic switch that acts to repress a multiple dendritic arbor and promote single-dendrite morphology
- Hand
- Member of a conserved family of bHLH transcription factors that performs a conserved function in cardiogenesis - also required for hematopoiesis
- headcase
-
novel basic protein - expression prefigures the mitotic activation of imaginal tissue proliferation - regulates tracheal branching
- head involution defective (preferred name: Wrinkled)
-
death domain protein - programd cell death - cell death function required for the movement of the dorsal fold
- across the procephalon and clypeolabrum, a process that forms the frontal sac
- across the procephalon and clypeolabrum, a process that forms the frontal sac
- heartbroken (preferred name: stumps)
-
novel signal transduction protein functioning downstream of two FGF receptors -
- mutations are associated with defects in the migration and later specification of mesodermal and tracheal cells
- mutations are associated with defects in the migration and later specification of mesodermal and tracheal cells
- heartless (commonly known as Fibroblast growth factor receptor 1 or DFR-1)
- receptor tyrosine kinase - involved in the development of mesodermal and neuronal cells
- Heat shock factor
-
leucine zipper - transcription factor - functions to activate transcription of heat shock genes during heat stress
- hedgehog
-
Hedgehog N-terminal signaling domain and C-terminal autoprocessing domain - helps establish embryonic segmentation - a segment polarity intercellular signaling protein
- held out wings
-
KH motif - putative RNA-binding protein - functions in the migration and attachment of somatic muscle cells
- hemiperous
-
a kinase (MapKK/JunKK) involved is dorsal closure - required for the correct differentiation of epithelia
- HEM-protein (common alternative name: kette)
- alternatively a membrane associated and a cytosolic protein that transduces
information to the neuronal cytoskeleton affecting axon guidance
- Hepatocyte growth factor regulated tyrosine kinase substrate (common alternative name: Hrs)
- endososomal sorting of ubiquitinated receptors - targeting of EGFR, PVR, Notch, Hedgehog and Dpp receptors for degradation
- Hepatocyte nuclear factor 4
-
zinc finger transcription factor - mutants show defects in midgut, Malpighian tubule and salivary gland development
- hephaestus
- polypyrimidine tract binding protein - controls alternative splicing - required to attenuate Notch activity after ligand-dependent activation during wing development
- hermaphrodite
-
C2H2 zinc finger transcription factor - plays a permissive role in sex determination and differentiation - required for female sexual differentiation
- heterochromatin protein 1 (preferred name: Suppressor of variegation 205)
- chromodomain - Polycomb group - chromatin associated protein -
- required both for activation of heterochromatic genes and silencing of euchromatic genes
- required both for activation of heterochromatic genes and silencing of euchromatic genes
- hibris
-
Ig repeat transmembrane protein with fibronectin type III domain - a receptor involved in muscle cell fusion
- High mobility group protein D
-
transcription factor - HMG domain protein - responsible for transcriptional silencing during early development
- highwire
-
synaptic protein - B-box zinc finger superfamily - a negative regular of synaptic growth
- hiiragi (also known as poly(A) polymerase)
-
involved in both nuclear and cytoplasmic polyadenylation of mRNA
- hikaru genki
-
synaptic protein - IG superfamily - required at during pupariation for the formation of normal neural circuitry
- hindsight (preferred name: pebbled)
-
multiple zinc finger transcription factor - regulates some aspect of amnioserosal signalling to surrounding ectoderm promoting germ band retraction
- hippo
-
a serine/threonine kinase - acts in conjunction with Salvador and Warts to restrict cell growth - promotes cell death by decreasing the level of Thread, an inhibitor of apoptosis
- Histone H1
-
Chromatin component - linker histone - stabilize a higher order 30 nm diameter chromatin fiber that is fundamental to the structural organization of chromosomes
- Histone H2A variant
- replacement histone participates in an ordered cascade of events leading to the establishment of heterochromatin
- Histone H3
- Nucleosome component - core histone
- Histone H3.3A
- H3 histone subtype - deposition is coupled to transcription and continues while a gene is active -
- histone replacement suggests a mechanism to maintain both the structure of chromatin and access to DNA at active genes
- histone replacement suggests a mechanism to maintain both the structure of chromatin and access to DNA at active genes
- Histone H4
-
Nucleosome component - core histone - acetylation of Histone H4 plays a positive role in promoting access of transcription factors to nucleosomal DNA
- HMG Coenzyme A reductase (common alternative name: columbus)
-
catalyzes the biosynthesis of a mevalonate precursor for isoprenoids - functions in the hedgehog signaling pathway, implicated in the production of a signal by the somatic gonadal precursor cells that attracts migrating germ cells
- Hnf4
-
zinc finger transcription factor - mutants show defects in midgut, Malpighian tubule and salivary gland development
- homer
- scaffolding protein required for the function of neural networks controlling locomotor activity and behavioral plasticity
- homeless (preferred name: spindle E)
- homeless DE-H family of RNA-dependent ATPases - the failure to transport Bicoid and Oskar mRNAs is the earliest defect in RNA transport observed in spn-E mutants
- homothorax
-
homeodomain transcription factor - HM domain protein - required for Extradenticle nuclear localization -
- a partner of Hox genes - required for segmentation and proper head involution
- a partner of Hox genes - required for segmentation and proper head involution
- hopscotch (common alternative name: jak kinase and janus kinase)
-
janus family tyrosine kinase - regulates even-skipped during segmentation -
- mutation creates an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation.
- mutation creates an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation.
- Hormone receptor-like in 38
- nuclear receptor superfamily - participates in a second ecdysteroid signaling pathway that responds to a distinct class of ecdysteroids
- in a manner that is independent of EcR
- in a manner that is independent of EcR
- Hormone receptor-like in 46 (common alternative name: DHR3)
- transcription factor - nuclear receptor superfamily - a second tier regulator involved in Drosophila molting --
- acts negatively on Ecdysone receptor and postively on genes expressed subsequently in the molting hierarchy
- acts negatively on Ecdysone receptor and postively on genes expressed subsequently in the molting hierarchy
- Hormone-receptor-like in 78
-
nuclear receptor superfamily - mutants are blocked in their ability to trigger the mid-third instar regulatory hierarchy
- Hr4
-
steroid hormone receptor - coordinates growth and maturation in Drosophila by mediating endocrine responses
- to achieve critical weight during larval development
- to achieve critical weight during larval development
-
huckebein
FlyExpress: hkb terminal and neuroblast expression
-
tf - zinc finger - terminal gap gene - limits the extent of mesodermal development - required for proper endoderm formation
-
hunchback FlyExpress: hbgap and neuroblast expression
-
transcription factor - zinc finger - a gap gene later expressed in neuroblasts - required for proper temporal generation of cellular sublineages during neurogenesis
- huntingtin
- cytoskeletal scaffolding protein required for axonal transport
- hyperplastic discs
-
a HECT domain E3 ubiquitin ligase that is likely to act by targeting Cubitus interruptus and an unknown activator of hedgehog expression for proteolysis
- I
- I
- Ice
-
a dowstream effector caspase - activated during spermatogenesis and necessary
- for the removal of cytoplasm and the generation of functional sperm
- for the removal of cytoplasm and the generation of functional sperm
- Imitation SWI
-
transcription factor - ATPase domain - bromodomain - gene activator - a component of a nucleosome remodeling protein complex
- immune deficiency
-
a death domain protein involved in signal transduction during antibacterial immune response
- inactivation no afterpotential D
-
scaffolding protein - PDZ domain protein - involved in visual signal transduction
- inebriated
-
neurotransmitter:sodium symporter - mutations appear to cause increased excitability of the motor neuron by causing defective reuptake of a substrate neurotransmitter
- infraabdominal (preferred name: nuclear untranslated RNA gene iab-4)
-
directly inhibits Ubx activity in vivo - ectopic expression induces a classical homeotic mutant phenotype,
- the transformation of halteres into wings
- the transformation of halteres into wings
- Inner centromere protein
- a component of the chromosome passenger complex - regulates activity of Aurora B kinase through a positive-feedback
- loop - as a microtubule-binding protein Incenp has a well-defined centromere-targeting domain at its
- N-terminus, suggesting a role in targeting the kinase to particular locations within the mitotic cell
- loop - as a microtubule-binding protein Incenp has a well-defined centromere-targeting domain at its
- Inositol 1,4,5,-tris-phosphate receptor
-
calcium channel - required for embryonic and larval development - involved in muscle development and is implicated in chemosensory functions
- inscuteable
-
novel protein - SH3 binding domain, ankyrin repeats and cytoskeletal attachment domain - involved in establishment apical/basal polarity
- Insulin-like receptor
-
receptor tyrosine kinase - a key component of an evolutionarily conserved signaling pathway that plays an essential role in controlling body, organ, and cell size
- integrin - ß PS (preferred name myospheroid)
- transmembrane - integrin - ß subunit - a major component of the cell's machinery
- for adherence to substrate, based on a calcium dependent process that produces a focal adhesion plaque
- for adherence to substrate, based on a calcium dependent process that produces a focal adhesion plaque
- Integrin linked kinase
-
s/t kinase with ankyrin repeats - required for integrin-mediated adhesion - links the cytoskeleton via integrins to the plasma membrane
- intermediate neuroblasts defective
-
homeodomain protein - determines the identity of the ventral most column of neuroblasts
- invected
-
transcription factor - homeodomain - engrailed class - cooperates with engrailed in establishing posterior compartment identity
- IplI-aurora-like kinase (alternative name: Aurora B)
- signaling protein involved in chromatin condensation during mitosis
- Ipou (preferred name: Abnormal chemosensory jump 6)
- transcription factor - homeodomain and POU domain - determines odorant response profile of subsets of olfactory neurons
- islet (preferred name: tailup)
-
transcription factor - homeodomain and LIM domain - required in combination with other transcription factors for serotonergic and dopaminergic neuron identity
- ISWI (preferred name: Imitation SWI)
-
transcription factor - ATPase domain - bromodomain - gene activator - a component of a nucleosome remodeling protein complex
- J
- J
- jaguar
- Drosophila myosin VI, a pointed end directed molecular motor - involved in asymmetric cell division -
- regulates actin dynamics during sperm individualization
- regulates actin dynamics during sperm individualization
- jak kinase (preferred name: hopscotch, common alternative name: janus kinase)
-
janus family tyrosine kinase - regulates even-skipped during segmentation -
- mutation creates an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation.
- mutation creates an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation.
- jelly belly
- a secreted ligand that contains an LDL receptor repeat - required for visceral mesoderm development
- JIL-1
- protein serine/threonine kinase involved in dosage compensation
- jing
- zinc finger transcription factor - a downstream target of slbo required for border cell migration -
- also plays an essential role in controlling CNS midline and tracheal cell differentiation
- also plays an essential role in controlling CNS midline and tracheal cell differentiation
- Jumeaux (preferred name: Domina)
-
forkhead/winged-helix class - a suppressor
of position effect variegation that affects and regulates eye and bristle development
- Jun amino terminal kinase (JNK) (preferred name: basket)
-
MAP kinase homolog - regulates cell shape change and
epidermal layer movement during dorsal closure
- Jun related antigen (common alternative name: DJun)
-
transcription factor - basic leucine zipper - cooperates with the ETS domain protein Pointed to induce R7 fate in the developing eye
- K
- K
- kakapo - preferred name: short stop
-
cytoskeletal cross-linker protein - expressed in the
tendons and is essential for muscle-dependent tendon cell differentiation -
- required for sensory and motor axons to reach their targets in the Drosophila embryo
- required for sensory and motor axons to reach their targets in the Drosophila embryo
- karst (common alternative name: betaHeavy Spectrin)
-
cytoskeletal protein - structural and docking protein - a junctional protein involved in cell adhesion
- kayak (common alternative name: Fos-related antigen)
-
transcription factor - basic leucine zipper - regulates dorsal closure - also required downstream from Decapentaplegic signaling for the regulation of labial in the midgut
- kekkon-1
-
Ig domain protein, Leucine-rich repeat protein - plays a role in axonal outgrowth in the central nervous system -
- acts in a negative feedback loop to modulate the activity of the Egfr tyrosine kinase during oogenesis
- acts in a negative feedback loop to modulate the activity of the Egfr tyrosine kinase during oogenesis
- kelch
- cytoskeletal protein - actin cross-linker - during oogenesis, phosphorylation of Kelch is critical for the proper morphogenesis of actin during ring canal growth
- kette (preferred name: HEM-protein)
- alternatively a membrane associated and a cytosolic protein that transduces
information to the neuronal cytoskeleton affecting axon guidance
- kinase suppressor of ras
- Ras pathway scaffolding protein - Ksr associates independently with Raf and Mek, and these interactions facilitate formation of a RAF/MEK complex thus promoting signaling through the Ras pathway
- Kinesin associated protein 3
-
the non-motor accessory subunit of Kinesin II - involved in intraflagellar transport - required for the axoneme growth and maintenance of the cilia in Drosophila type I sensory neurons -
- expressed in Johnston's organ and required for hearing
- expressed in Johnston's organ and required for hearing
- Kinesin heavy chain
-
plus end directed vesicular transport motor protein
- kin of irre (common alternative name: dumbfounded)
- IG superfamily - required for myoblast aggregation and fusion
- kismet
- member of the SWI2/SNF2 family of ATP-dependent chromatin-remodeling factors - facilitates an early step in transcriptional elongation by Pol II
- klarsicht
- controls bidirectional transport of lipid droplets, nuclear migration and transport of secretory vesicles
- klumpfuss
-
transcription factor - zinc finger - early growth response family - involved in determination of the identities of secondary precursor cells within neuroblast lineages in the central nervous system.
- knirps
-
transcription factor - steroid receptor - zinc finger - a gap gene that later organizes the development of the second wing vein
-
knot (common alternative name: collier)
FlyExpress: knot expression in mandibular segment anlage
-
EBF/Olf-1 homolog, HLH protein - required for the formation of the hypopharyngeal lobe
-
Krüppel
FlyExpress: Kr gap, hindgut and CNS expression
-
transcription factor - zinc finger transcriptional repressor - gap gene required later for proper generation of neural sublineages
- kuzbanian
- disintegrin and metalloprotease motifs - neurogenic gene
-
Genes A-D-- Genes L-R -- Genes S-Z
Home page: The Interactive Fly © 1995, 1996 Thomas B. Brody, Ph.D.